Aspirin and the Risk of Colorectal Cancer in Relation to the Expression of 15-Hydroxyprostaglandin Dehydrogenase ( HPGD )

Author:

Fink Stephen P.1,Yamauchi Mai2,Nishihara Reiko23,Jung Seungyoun4,Kuchiba Aya23,Wu Kana34,Cho Eunyoung45,Giovannucci Edward346,Fuchs Charles S.24,Ogino Shuji2678,Markowitz Sanford D.1,Chan Andrew T.49

Affiliation:

1. Department of Medicine and Case Comprehensive Cancer Center, Case Western Reserve University and University Hospitals Case Medical Center, 10900 Euclid Avenue, Cleveland, OH 44106, USA.

2. Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215, USA.

3. Department of Nutrition, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA.

4. Channing Division of Network Medicine, Brigham and Women’s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA.

5. Department of Dermatology, Warren Alpert Medical School of Brown University, 339 Eddy Street, Providence, RI 02903, USA.

6. Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA.

7. Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.

8. Department of Pathology, Brigham and Women’s Hospital, Boston and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.

9. Division of Gastroenterology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.

Abstract

Aspirin use is associated with a lower risk of colorectal cancer arising in association with high expression of 15-PGDH ( HPGD ) in normal colon mucosa.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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