Detection of 2-Hydroxyglutarate in IDH -Mutated Glioma Patients by In Vivo Spectral-Editing and 2D Correlation Magnetic Resonance Spectroscopy-Reference-Cited by-同舟云学术

Detection of 2-Hydroxyglutarate in IDH -Mutated Glioma Patients by In Vivo Spectral-Editing and 2D Correlation Magnetic Resonance Spectroscopy

Published:2012-01-11 Issue:116 Volume:4 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Andronesi Ovidiu C.¹,Kim Grace S.¹,Gerstner Elizabeth²,Batchelor Tracy²,Tzika Aria A.¹³,Fantin Valeria R.⁴,Vander Heiden Matthew G.⁵⁶,Sorensen A. Gregory¹

Affiliation:

1. Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

2. Pappas Center for Neuro-Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

3. NMR Surgical Laboratory, Department of Surgery, Massachusetts General Hospital and Shriners Burn Institute, Harvard Medical School, Boston, MA 02114, USA.

4. Agios Pharmaceuticals, Cambridge, MA 02139, USA.

5. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

6. Dana-Farber Cancer Institute, Boston, MA 02115, USA.

Abstract

2-Hydroxyglutarate, a metabolite overproduced in IDH -mutated gliomas, can be detected noninvasively in patients with brain tumors by optimized magnetic resonance spectroscopy.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference37 articles.

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4. Isocitrate dehydrogenase-1 mutations: a fundamentally new understanding of diffuse glioma?

5. The prognostic IDH1 R132 mutation is associated with reduced NADP+-dependent IDH activity in glioblastoma

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