Dynamics of Dengue Disease Severity Determined by the Interplay Between Viral Genetics and Serotype-Specific Immunity

Author:

OhAinle Molly1,Balmaseda Angel2,Macalalad Alexander R.3,Tellez Yolanda2,Zody Michael C.3,Saborío Saira2,Nuñez Andrea2,Lennon Niall J.3,Birren Bruce W.3,Gordon Aubree1,Henn Matthew R.3,Harris Eva1

Affiliation:

1. Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA 94720–7354, USA.

2. Laboratorio Nacional de Virología, Centro Nacional de Diagnóstico y Referencia, Ministry of Health, Managua, Nicaragua.

3. Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

Abstract

The complex interactions between serotype-specific immunity and viral genetics drive dengue disease outcomes in endemic populations.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference95 articles.

1. World Health Organization Dengue Haemorrhagic Fever: Diagnosis Treatment Prevention and Control (World Health Organization Geneva ed. 2 1997).

2. Dengue

3. RISK FACTORS IN DENGUE SHOCK SYNDROME: A PROSPECTIVE EPIDEMIOLOGIC STUDY IN RAYONG, THAILAND

4. Risk Factors in Dengue Shock Syndrome

5. A Prospective Study of Dengue Infections in Bangkok

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