COX-2 Inhibition Potentiates Antiangiogenic Cancer Therapy and Prevents Metastasis in Preclinical Models-Reference-Cited by-同舟云学术

COX-2 Inhibition Potentiates Antiangiogenic Cancer Therapy and Prevents Metastasis in Preclinical Models

Published:2014-06-25 Issue:242 Volume:6 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Xu Lihong¹,Stevens Janine¹,Hilton Mary Beth¹²,Seaman Steven¹,Conrads Thomas P.³,Veenstra Timothy D.³,Logsdon Daniel²,Morris Holly⁴,Swing Deborah A.⁴,Patel Nimit L.⁵,Kalen Joseph⁵,Haines Diana C.⁶,Zudaire Enrique¹,St. Croix Brad¹

Affiliation:

1. Tumor Angiogenesis Section, Mouse Cancer Genetics Program (MCGP), National Cancer Institute (NCI) at Frederick, National Institutes of Health, Frederick, MD 21702, USA.

2. Basic Research Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.

3. Laboratory of Proteomics and Analytical Technologies, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.

4. Transgenic Core Facility, MCGP, NCI, Frederick, MD 21702, USA.

5. Small Animal Imaging Program/LASP, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.

6. Pathology/Histotechnology Laboratory, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.

Abstract

Inhibition of cyclooxygenase-2 (COX-2) inhibits angiogenesis, suppresses tumor growth, and augments the effects of traditional angiogenesis inhibitors.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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5. Use of anti-VEGF adjuvant therapy in cancer: challenges and rationale

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