Polyfunctional Fc-Effector Profiles Mediated by IgG Subclass Selection Distinguish RV144 and VAX003 Vaccines-Reference-Cited by-同舟云学术

Polyfunctional Fc-Effector Profiles Mediated by IgG Subclass Selection Distinguish RV144 and VAX003 Vaccines

Published:2014-03-19 Issue:228 Volume:6 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Chung Amy W.¹,Ghebremichael Musie¹,Robinson Hannah¹,Brown Eric²,Choi Ickwon³,Lane Sophie¹,Dugast Anne-Sophie¹,Schoen Matthew K.¹,Rolland Morgane⁴,Suscovich Todd J.¹,Mahan Alison E.¹,Liao Larry⁵,Streeck Hendrik⁴,Andrews Charla⁴,Rerks-Ngarm Supachai⁶,Nitayaphan Sorachai⁷,de Souza Mark S.⁷,Kaewkungwal Jaranit⁸,Pitisuttithum Punnee⁸,Francis Donald⁹,Michael Nelson L.⁴,Kim Jerome H.⁴,Bailey-Kellogg Chris³,Ackerman Margaret E.²,Alter Galit¹

Affiliation:

1. Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard, Boston, MA 02139, USA.

2. Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA.

3. Department of Computer Science, Dartmouth College, Hanover, NH 03755, USA.

4. Department of Molecular Virology and Pathogenesis, Walter Reed Army Institute of Research, U.S. Military HIV Research Program, Silver Spring, MD 20910, USA.

5. Duke University Human Vaccine Institute and the Center for HIV/AIDS Vaccine Immunology, Durham, NC 27710, USA.

6. Department of Disease Control, Ministry of Public Health, Nonthaburi 11000, Thailand.

7. Armed Forces Research Institute of Medical Sciences, Bangkok 10400, Thailand.

8. Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.

9. Global Solutions for Infectious Diseases, Brisbane, CA 94005, USA.

Abstract

RV144 vaccination induced polyfunctional antibody Fc-effector responses, whereas VAX003 vaccination increased inhibitory IgG4 antibodies.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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5. Functional and immunochemical cross-reactivity of V2-specific monoclonal antibodies from HIV-1-infected individuals

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