Silencing HoxA1 by Intraductal Injection of siRNA Lipidoid Nanoparticles Prevents Mammary Tumor Progression in Mice-Reference-Cited by-同舟云学术

Silencing HoxA1 by Intraductal Injection of siRNA Lipidoid Nanoparticles Prevents Mammary Tumor Progression in Mice

Published:2014-01 Issue:217 Volume:6 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Brock Amy¹,Krause Silva²,Li Hu¹,Kowalski Marek¹,Goldberg Michael S.³,Collins James J.¹⁴,Ingber Donald E.¹²

Affiliation:

1. Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.

2. Vascular Biology Program, Boston Children’s Hospital and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.

3. Dana-Farber Cancer Research Institute, Harvard Medical School, Boston, MA 02115, USA.

4. Howard Hughes Medical Institute, Boston University, Boston, MA 02115, USA.

Abstract

Silencing of HoxA1 with nanoparticle siRNA prevented loss of hormone receptor expression, suppressed cell proliferation, and reduced mammary tumor incidence in mice.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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