Genome-Wide Mutational Signatures of Aristolochic Acid and Its Application as a Screening Tool-Reference-Cited by-同舟云学术

Genome-Wide Mutational Signatures of Aristolochic Acid and Its Application as a Screening Tool

Published:2013-08-07 Issue:197 Volume:5 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Poon Song Ling¹²,Pang See-Tong³,McPherson John R.²,Yu Willie¹²⁴,Huang Kie Kyon²⁵,Guan Peiyong⁶,Weng Wen-Hui⁷,Siew Ee Yan¹²,Liu Yujing²⁸,Heng Hong Lee¹²,Chong Soo Ching¹²,Gan Anna¹²,Tay Su Ting⁹,Lim Weng Khong¹²,Cutcutache Ioana²,Huang Dachuan¹²,Ler Lian Dee¹²⁴,Nairismägi Maarja-Liisa¹²,Lee Ming Hui⁹,Chang Ying-Hsu³,Yu Kai-Jie³,Chan-on Waraporn¹²,Li Bin-Kui¹⁰,Yuan Yun-Fei¹¹,Qian Chao-Nan¹¹,Ng Kwai-Fong¹²,Wu Ching-Fang¹³,Hsu Cheng-Lung¹⁴,Bunte Ralph M.¹⁵,Stratton Michael R.¹⁶,Futreal P. Andrew¹⁷,Sung Wing-Kin¹⁶¹⁸,Chuang Cheng-Keng³,Ong Choon Kiat¹²,Rozen Steven G.²¹⁹,Tan Patrick²⁵⁹¹⁸,Teh Bin Tean¹²⁵

Affiliation:

1. NCCS-VARI Translational Research Laboratory, Division of Medical Sciences, National Cancer Centre Singapore, 11 Hospital Drive, Singapore 169610, Singapore.

2. Program in Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, 8 College Road, Singapore 169857, Singapore.

3. Division of Urology, Department of Surgery, Chang Gung Memorial Hospital, Linkou; School of Medicine, Chang Gung University, 5, Fusing Street, Gueishan Township, Taoyuan County 333, Taiwan.

4. National University of Singapore Graduate School for Integrative Sciences and Engineering, 28 Medical Drive, Singapore 117456, Singapore.

5. Cancer Science Institute of Singapore, National University of Singapore, Centre for Life Sciences, 28 Medical Drive, Singapore 117456, Singapore.

6. School of Computing, National University of Singapore, 21 Lower Kent Ridge Road, Singapore 119077, Singapore.

7. Department of Chemical Engineering and Biotechnology, Graduate Institute of Biotechnology, National Taipei University of Technology, 1, Section 3, Chung-hsiao East Road, Taipei 10608, Taiwan.

8. Computational and Systems Biology, Singapore-MIT Alliance, National University of Singapore, Singapore 119077, Singapore.

9. Division of Cellular and Molecular Research, National Cancer Centre Singapore, 11 Hospital Drive, Singapore 169610, Singapore.

10. Department of Hepatobiliary Oncology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060, China.

11. State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060, China.

12. Department of Pathology, Chang Gung Memorial Hospital, Linkou; School of Medicine Chang Gung University, Taoyuan County 333, Taiwan.

13. Division of Urology, Department of Surgery, Chang Gung Memorial Hospital, Chiayi; School of Traditional Chinese Medicine, Chang Gung University, Taoyuan County 333, Taiwan.

14. Division of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan County 333, Taiwan.

15. Office of Research, Duke-NUS Graduate Medical School, Singapore 169857, Singapore.

16. Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK.

17. Genomic Medicine, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1954, Houston, TX 77030, USA.

18. Genome Institute of Singapore, 60 Biopolis Street Genome, Singapore 138672, Singapore.

19. Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA.

Abstract

Genome-wide mutational signatures of the group 1 carcinogen aristolochic acid are observed in urothelial cancers and liver cancers from Asia.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference51 articles.

1. Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes

2. Exome sequencing of liver fluke–associated cholangiocarcinoma

3. Mapping the Hallmarks of Lung Adenocarcinoma with Massively Parallel Sequencing

4. Melanoma genome sequencing reveals frequent PREX2 mutations

5. Aristolochia Manshuriensis Kom Inhibits Adipocyte Differentiation by Regulation of ERK1/2 and Akt Pathway

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