Mechanism of praziquantel action at a parasitic flatworm ion channel-Reference-Cited by-同舟云学术

Mechanism of praziquantel action at a parasitic flatworm ion channel

Published:2021-12-22 Issue:625 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Park Sang-Kyu¹^ORCID,Friedrich Lukas²^ORCID,Yahya Nawal A.¹³^ORCID,Rohr Claudia M.¹^ORCID,Chulkov Evgeny G.¹^ORCID,Maillard David⁴,Rippmann Friedrich²^ORCID,Spangenberg Thomas⁵^ORCID,Marchant Jonathan S.¹^ORCID

Affiliation:

1. Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee WI 53226, USA.

2. Computational Chemistry and Biology, Global Research & Development, Discovery Technologies, Merck Healthcare, Frankfurter Str. 250, 64293 Darmstadt, Germany.

3. Department of Pharmacology, University of Minnesota Medical School, 312 Church Street, Minneapolis, MN 55455, USA.

4. Central Process Development - Downstream Processing Services, Merck Performance Materials, Frankfurter Street 250, 64293 Darmstadt, Germany.

5. Global Health Institute of Merck, Ares Trading S.A., a subsidiary of Merck KGaA, Darmstadt, Germany, 1262 Eysins, Switzerland.

Abstract

Parasitic flatworm sensitivity to praziquantel is determined by amino acid variation in the binding pocket of a TRP channel.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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