In vivo and neuropathology data support locus coeruleus integrity as indicator of Alzheimer’s disease pathology and cognitive decline

Author:

Jacobs Heidi I. L.123ORCID,Becker John A.12ORCID,Kwong Kenneth24,Engels-Domínguez Nina13ORCID,Prokopiou Prokopis C.12ORCID,Papp Kathryn V.25ORCID,Properzi Michael26ORCID,Hampton Olivia L.6,d’Oleire Uquillas Federico7ORCID,Sanchez Justin S.1ORCID,Rentz Dorene M.256ORCID,El Fakhri Georges12,Normandin Marc D.12ORCID,Price Julie C.24,Bennett David A.8ORCID,Sperling Reisa A.256ORCID,Johnson Keith A.126ORCID

Affiliation:

1. Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.

2. Harvard Medical School, Boston, MA 02115, USA.

3. Faculty of Health, Medicine and Life Sciences, School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, 6200 MD Maastricht, Netherlands.

4. The Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA 02129, USA.

5. Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women’s Hospital, Boston, MA 02115, USA.

6. Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.

7. Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA.

8. Department of Neurological Sciences, Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA.

Abstract

In vivo and autopsy evidence supports locus coeruleus MRI measures as proxy of initial TAU deposition and amyloid-related memory decline.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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