A phase 1/2 clinical trial of the nitric oxide synthase inhibitor L-NMMA and taxane for treating chemoresistant triple-negative breast cancer

Author:

Chung Andrew W.123ORCID,Anand Kartik3ORCID,Anselme Ann C.123ORCID,Chan Alfred A.4,Gupta Nakul5ORCID,Venta Luz A.5ORCID,Schwartz Mary R.6ORCID,Qian Wei23,Xu Yitian23ORCID,Zhang Licheng23ORCID,Kuhn John7,Patel Tejal38,Rodriguez Angel A.9ORCID,Belcheva Anna3,Darcourt Jorge3ORCID,Ensor Joe3ORCID,Bernicker Eric3ORCID,Pan Ping-Ying23ORCID,Chen Shu Hsia23ORCID,Lee Delphine J.410ORCID,Niravath Polly A.3ORCID,Chang Jenny C.23ORCID

Affiliation:

1. Texas A&M University Health Science Center, Bryan, TX 77807, USA.

2. Houston Methodist Research Institute, Houston, TX 77030, USA.

3. Houston Methodist Cancer Center, Houston, TX 77030, USA.

4. Lundquist Institute, Torrance, CA 90502, USA.

5. Department of Radiology, Houston Methodist Hospital, Houston, TX 77030, USA.

6. Houston Methodist Department of Pathology and Genomic Medicine, Houston, TX 77030, USA.

7. University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.

8. Department of General Oncology MD Anderson Cancer Center, Houston, TX 77030, USA.

9. Austin Cancer Center, Austin, TX 78705, USA.

10. David Geffen School of Medicine at Los Angeles, CA 90095, USA.

Abstract

A phase 1/2 clinical trial in patients with chemoresistant triple-negative breast cancer targets the inducible nitric oxide signaling pathway.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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