A dysbiotic microbiome triggers T H 17 cells to mediate oral mucosal immunopathology in mice and humans-Reference-Cited by-同舟云学术

A dysbiotic microbiome triggers T H 17 cells to mediate oral mucosal immunopathology in mice and humans

Published:2018-10-17 Issue:463 Volume:10 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Dutzan Nicolas¹²^ORCID,Kajikawa Tetsuhiro³^ORCID,Abusleme Loreto¹²^ORCID,Greenwell-Wild Teresa¹,Zuazo Carlos E.¹,Ikeuchi Tomoko¹^ORCID,Brenchley Laurie¹,Abe Toshiharu³^ORCID,Hurabielle Charlotte⁴⁵,Martin Daniel⁶^ORCID,Morell Robert J.⁶,Freeman Alexandra F.⁷,Lazarevic Vanja⁸,Trinchieri Giorgio⁹,Diaz Patricia I.¹⁰^ORCID,Holland Steven M.⁷^ORCID,Belkaid Yasmine⁴^ORCID,Hajishengallis George³^ORCID,Moutsopoulos Niki M.¹^ORCID

Affiliation:

1. Oral Immunity and Inflammation Unit, NIDCR, NIH, Bethesda, MD 20892, USA.

2. Faculty of Dentistry, University of Chile, 8380492 Santiago, Chile.

3. Department of Microbiology, Penn Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

4. Mucosal Immunology Section, Laboratory of Parasitic Diseases, NIAID, NIH, MD 20892, USA.

5. Inserm U976, Hôpital Saint Louis, Université Paris Diderot, Paris 75010, France.

6. Genomics and Computational Biology Core, NIDCD, NIH, Bethesda, MD 20892, USA.

7. Laboratory of Clinical Immunology and Microbiology (LCIM), NIAID, NIH, Bethesda, MD 20892, USA.

8. Experimental Immunology Branch, Center for Cancer Research, NCI, NIH, Bethesda, MD 20892, USA.

9. Cancer and Inflammation Program, CCR, NCI, NIH, Bethesda, MD 20892, USA.

10. School of Dental Medicine, UConn Health, Farmington, CT 06030, USA.

Abstract

Combined patient and animal model studies implicate microbiota-triggered T H 17 cells as disease drivers and therapeutic targets in periodontitis.

Funder

Fondation pour la Recherche Médicale

NIAID

NIDCR

NCI Intramural

La Roche-Posay

CEDEF

Philippe Foundation

fondation groupe pasteur mutualité

Société Française de Dermatologie

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference58 articles.

1. Update on Prevalence of Periodontitis in Adults in the United States: NHANES 2009 to 2012

2. Periodontitis: from microbial immune subversion to systemic inflammation

3. Evidence of the presence of T helper type 17 cells in chronic lesions of human periodontal disease

4. IL-23-producing CD68+ macrophage-like cells predominate within an IL-17-polarized infiltrate in chronic periodontitis lesions

5. IL-17: overview and role in oral immunity and microbiome

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