Elastin imaging enables noninvasive staging and treatment monitoring of kidney fibrosis

Author:

Sun Qinxue12ORCID,Baues Maike3ORCID,Klinkhammer Barbara M.14ORCID,Ehling Josef3,Djudjaj Sonja1ORCID,Drude Natascha I.35,Daniel Christoph6ORCID,Amann Kerstin6,Kramann Rafael4,Kim Hyojin78ORCID,Saez-Rodriguez Julio78ORCID,Weiskirchen Ralf9ORCID,Onthank David C.10ORCID,Botnar Rene M.11,Kiessling Fabian3ORCID,Floege Jürgen4,Lammers Twan312ORCID,Boor Peter141314ORCID

Affiliation:

1. Institute of Pathology, RWTH Aachen University Hospital, 52074 Aachen, Germany.

2. Department of Radiology, Ningbo Medical Center Li Huili Hospital, 315040 Ningbo, China.

3. Institute for Experimental Molecular Imaging, RWTH Aachen University Hospital, 52074 Aachen, Germany.

4. Department of Nephrology and Immunology, RWTH Aachen University Hospital, 52074 Aachen, Germany.

5. Department for Nuclear Medicine, RWTH Aachen University Hospital, 52074 Aachen, Germany.

6. Institute of Pathology and Department of Nephropathology, University Erlangen, 91054 Erlangen, Germany.

7. Joint Research Center for Computational Biomedicine, RWTH Aachen University Hospital, 52074 Aachen, Germany.

8. Institute of Computational Biomedicine, Heidelberg University, 69120 Heidelberg, Germany.

9. Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry, RWTH Aachen University Hospital, 52074 Aachen, Germany.

10. Lantheus Medical Imaging, North Billerica, MA 01862, USA.

11. School of Biomedical Engineering and Imaging Sciences, King's College London, WC2R 2LS London, UK.

12. Department of Targeted Therapeutics, University of Twente, 7522 NB Enschede, Netherlands.

13. Electron Microscopy Facility, RWTH Aachen University Hospital, 52074 Aachen, Germany.

14. Institute of Molecular Biomedicine, Comenius University, 81972 Bratislava, Slovakia.

Abstract

Elastin-specific MRI allows quantitative and longitudinal renal fibrosis assessment and monitoring of treatment efficacy.

Funder

H2020 European Research Council

Deutsche Forschungsgemeinschaft

Bundesministerium für Bildung und Forschung

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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