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Cholesterol, cancer, and rebooting a treatment for athlete’s foot

Published:2018-04-18 Issue:437 Volume:10 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Chua Ngee Kiat¹^ORCID,Coates Hudson W.¹,Brown Andrew J.¹^ORCID

Affiliation:

1. School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales 2052, Australia.

Abstract

A key enzyme in cholesterol synthesis is placed firmly on the oncogenic map and demonstrated to be a potential therapeutic target in liver cancer by repurposing a common antifungal agent (Liu et al ., this issue).

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference10 articles.

1. The Role of Cholesterol in the Pathogenesis of NASH

2. Squalene epoxidase drives NAFLD-induced hepatocellular carcinoma and is a pharmaceutical target

3. Cholesterol-Dependent Degradation of Squalene Monooxygenase, a Control Point in Cholesterol Synthesis beyond HMG-CoA Reductase

4. Cellular cholesterol trafficking and compartmentalization

5. Cholesterol Metabolism and Prostate Cancer Lethality

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