Gallium disrupts bacterial iron metabolism and has therapeutic effects in mice and humans with lung infections

Author:

Goss Christopher H.12ORCID,Kaneko Yukihiro3,Khuu Lisa4ORCID,Anderson Gail D.5,Ravishankar Sumedha4ORCID,Aitken Moira L.1,Lechtzin Noah6ORCID,Zhou Guolin7,Czyz Daniel M.8,McLean Kathryn9ORCID,Olakanmi Oyebode10,Shuman Howard A.8ORCID,Teresi Mary11,Wilhelm Ellen1ORCID,Caldwell Ellen1,Salipante Stephen J.9ORCID,Hornick Douglas B.11,Siehnel Richard J.4ORCID,Becker Lev7,Britigan Bradley E.12,Singh Pradeep K.14ORCID

Affiliation:

1. Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA.

2. Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195, USA.

3. Department of Bacteriology, Osaka City University School of Medicine, Osaka 545-0051, Japan.

4. Department of Microbiology, University of Washington School of Medicine, Seattle, WA 98195, USA.

5. Department of Pharmacy, University of Washington School of Pharmacy, Seattle, WA 98195, USA.

6. Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

7. Ben May Department for Cancer Research, University of Chicago, Chicago, IL 60637, USA.

8. Department of Microbiology, The University of Chicago, Chicago, IL 60637, USA.

9. Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA.

10. University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.

11. Department of Medicine, University of Nebraska School of Medicine, Omaha, NE 68105, USA.

12. Departments of Medicine and Pediatrics, University of Iowa, Iowa City, IA 52242, USA.

Abstract

Gallium disrupts bacterial iron metabolism and treats infections in mice and patients with chronic airway infections.

Funder

NIH Office of the Director

Burroughs Wellcome Fund

Cystic Fibrosis Foundation

Arcadia Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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