APOE3 -Jacksonville (V236E) variant reduces self-aggregation and risk of dementia-Reference-Cited by-全球学者库

APOE3 -Jacksonville (V236E) variant reduces self-aggregation and risk of dementia

Published:2021-09-29 Issue:613 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Liu Chia-Chen¹^ORCID,Murray Melissa E.¹^ORCID,Li Xia¹^ORCID,Zhao Na¹^ORCID,Wang Na¹,Heckman Michael G.²,Shue Francis¹^ORCID,Martens Yuka¹^ORCID,Li Yonghe¹,Raulin Ana-Caroline¹^ORCID,Rosenberg Cassandra L.¹,Doss Sydney V.¹^ORCID,Zhao Jing¹^ORCID,Wren Melissa C.¹^ORCID,Jia Lin¹,Ren Yingxue²,Ikezu Tadafumi C.¹^ORCID,Lu Wenyan¹,Fu Yuan¹,Caulfield Thomas¹^ORCID,Trottier Zachary A.¹^ORCID,Knight Joshua¹,Chen Yixing¹,Linares Cynthia¹,Wang Xue²,Kurti Aishe¹,Asmann Yan W.²,Wszolek Zbigniew K.³^ORCID,Smith Glenn E.⁴,Vemuri Prashanthi⁵^ORCID,Kantarci Kejal⁵,Knopman David S.⁶,Lowe Val J.⁵,Jack Clifford R.⁵^ORCID,Parisi Joseph E.⁶⁷,Ferman Tanis J.⁸^ORCID,Boeve Bradley F.⁶^ORCID,Graff-Radford Neill R.³,Petersen Ronald C.⁶^ORCID,Younkin Steven G.¹^ORCID,Fryer John D.⁹,Wang Hu¹⁰,Han Xianlin¹⁰¹¹,Frieden Carl¹²^ORCID,Dickson Dennis W.¹^ORCID,Ross Owen A.¹¹³^ORCID,Bu Guojun¹^ORCID

Affiliation:

1. Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.

2. Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL 32224, USA.

3. Department of Neurology, Mayo Clinic, Jacksonville, FL 32224, USA.

4. Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905, USA.

5. Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA.

6. Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.

7. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.

8. Department of Psychiatry and Psychology, Mayo Clinic, Jacksonville, FL 32224, USA.

9. Department of Neuroscience, Mayo Clinic, Scottsdale, AZ 85259, USA.

10. Barshop Institute for Longevity and Aging Studies, San Antonio, TX 78229, USA.

11. Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.

12. Department of Biochemistry and Molecular Biophysics, Washington University, St. Louis, MO 63110, USA.

13. Department of Clinical Genomics, Mayo Clinic, Jacksonville, FL 32224, USA.

Abstract

A rare APOE variant APOE3 -Jac reduces self-aggregation and promotes healthy brain aging.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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