Bacterial cytoplasmic membranes synergistically enhance the antitumor activity of autologous cancer vaccines

Author:

Chen Long12ORCID,Qin Hao12ORCID,Zhao Ruifang123ORCID,Zhao Xiao12ORCID,Lin Liangru14,Chen Yang12,Lin Yixuan12,Li Yao15,Qin Yuting12,Li Yiye12,Liu Shaoli12,Cheng Keman15,Chen Hanqing6ORCID,Shi Jian1,Anderson Gregory J.7ORCID,Wu Yan12ORCID,Zhao Yuliang123ORCID,Nie Guangjun123ORCID

Affiliation:

1. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center of Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, P. R. China.

2. Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, P. R. China.

3. GBA National Institute for Nanotechnology Innovation, Guangdong 510700, P. R. China.

4. Jilin University, Changchun, Jilin 130012, P. R. China.

5. Xiamen University, Xiamen, Fujian 361005, P. R. China.

6. Department of Gastroenterology, Guangzhou Digestive Disease Center, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou 510180, Guangdong, P. R. China.

7. QIMR Berghofer Medical Research Institute, Royal Brisbane Hospital, Queensland 4029, Australia.

Abstract

A nanovaccine based on bacterial cytoplasmic membranes and cell membranes from resected tumor tissue prevents tumor recurrence in mice.

Funder

Innovative Research Group Project of the National Natural Science Foundation of China

National Natural Science Foundation of China

Beijing Nova Program

Beijing Natural Science Foundation of China

the Key Area R&D Program of Guangdong Province

the National Basic Research Plan of China

the Strategic Priority Research Program of Chinese Academy of Sciences

the K.C. Wong Education Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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