Anti-tau antibody administration increases plasma tau in transgenic mice and patients with tauopathy-Reference-Cited by-同舟云学术

Anti-tau antibody administration increases plasma tau in transgenic mice and patients with tauopathy

Published:2017-04-19 Issue:386 Volume:9 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Yanamandra Kiran¹²,Patel Tirth K.¹,Jiang Hong¹,Schindler Suzanne¹,Ulrich Jason D.¹,Boxer Adam L.³,Miller Bruce L.³,Kerwin Diana R.⁴,Gallardo Gilbert¹,Stewart Floy¹,Finn Mary Beth¹,Cairns Nigel J.¹,Verghese Philip B.⁵,Fogelman Ilana⁵,West Tim⁵,Braunstein Joel⁵,Robinson Grace¹,Keyser Jennifer¹,Roh Joseph¹,Knapik Stephanie S.⁵,Hu Yan⁵,Holtzman David M.¹

Affiliation:

1. Hope Center for Neurological Disorders and Knight Alzheimer’s Disease Research Center, Department of Neurology, Washington University, St. Louis, MO 63110,USA.

2. AbbVie Inc. Foundational Neuroscience Center, Cambridge, MA 02139, USA.

3. Clinical Trials Program, Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA.

4. Texas Alzheimer’s and Memory Disorders, Texas Health Presbyterian Hospital Dallas, Dallas, TX 75231, USA.

5. C2N Diagnostics, Center for Emerging Technologies, 4041 Forest Park Avenue, St. Louis, MO 63108, USA.

Abstract

Administration of an anti-tau antibody to transgenic mice expressing human tau and to patients with tauopathy increased the concentration of tau in plasma.

Funder

JPB Foundation

NIH

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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