In situ identification of Gram-negative bacteria in human lungs using a topical fluorescent peptide targeting lipid A-Reference-Cited by-同舟云学术

In situ identification of Gram-negative bacteria in human lungs using a topical fluorescent peptide targeting lipid A

Published:2018-10-24 Issue:464 Volume:10 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Akram Ahsan R.¹²^ORCID,Chankeshwara Sunay V.¹³^ORCID,Scholefield Emma¹^ORCID,Aslam Tashfeen³,McDonald Neil²^ORCID,Megia-Fernandez Alicia¹³,Marshall Adam¹²^ORCID,Mills Bethany¹,Avlonitis Nicolaos³,Craven Thomas H.¹²^ORCID,Smyth Annya M.¹^ORCID,Collie David S.⁴^ORCID,Gray Calum⁵^ORCID,Hirani Nik²^ORCID,Hill Adam T.²,Govan John R.⁶,Walsh Timothy¹²^ORCID,Haslett Christopher¹²,Bradley Mark¹³^ORCID,Dhaliwal Kevin¹²^ORCID

Affiliation:

1. EPSRC IRC PROTEUS Hub, Centre for Inflammation Research, Queen’s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.

2. Centre for Inflammation Research, Queen’s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.

3. EaStCHEM, University of Edinburgh School of Chemistry, Joseph Black Building, West Mains Road, Edinburgh EH9 3FJ, UK.

4. The Roslin Institute and R(D)SVS, University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Midlothian EH25 9RG, UK.

5. Clinical Research Imaging Facility, Queen’s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.

6. Division of Infection and Pathway Medicine, University of Edinburgh, The Chancellor’s Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK.

Abstract

A topically administered fluorescently labeled peptide targeting lipid A permits rapid, real-time visualization of bacteria in the distal human lung.

Funder

Wellcome Trust

Engineering and Physical Sciences Research Council

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference54 articles.

1. Hospital-Acquired Infections Due to Gram-Negative Bacteria