Modular immune-homeostatic microparticles promote immune tolerance in mouse autoimmune models

Author:

Chen Xin1ORCID,Yang Xiaoshan2ORCID,Yuan Pingyun1ORCID,Jin Ronghua1ORCID,Bao Lili2ORCID,Qiu Xinyu2,Liu Siying2,Liu Tao1,Gooding John Justin3ORCID,Chen WanJun4,Liu Guozhen5ORCID,Bai Yongkang1ORCID,Liu Shiyu2ORCID,Jin Yan2ORCID

Affiliation:

1. School of Chemical Engineering and Technology, Shaanxi Key Laboratory of Energy Chemical Process Intensification, Institute of Polymer Science in Chemical Engineering, Xi’an Jiao Tong University, Xi’an, Shaanxi 710049, China.

2. State Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, Fourth Military Medical University, Xi’an, Shaanxi 710032, China.

3. School of Chemistry, Australian Centre for NanoMedicine and ARC Australian Centre of Excellence in Convergent Bio-Nano Science and Technology, University of New South Wales, Sydney 2052, Australia.

4. Mucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.

5. Graduate School of Biomedical Engineering, ARC Centre of Excellence for Nanoscale BioPhotonics and Australian Centre for NanoMedicine, Faculty of Engineering, University of New South Wales, Sydney 2052, Australia.

Abstract

Modular microparticles induce antigen-specific immune tolerance by inducing apoptosis and promoting T reg differentiation.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Young Elite Scientist Sponsorship Program by CAST

Fundamental Research Funds for the Central Universities, open fund of the State Key Laboratory of Military Stomatology

Knowledge Innovation Program of Shenzhen

ARC Centre of Excellence in Convergent Bio-Nano Science and Technology

ARC Laureate Fellowship program

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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