Paroxysmal slow cortical activity in Alzheimer’s disease and epilepsy is associated with blood-brain barrier dysfunction

Author:

Milikovsky Dan Z.1ORCID,Ofer Jonathan1ORCID,Senatorov Vladimir V.234,Friedman Aaron R.3ORCID,Prager Ofer1,Sheintuch Liron1ORCID,Elazari Netta1,Veksler Ronel1,Zelig Daniel1,Weissberg Itai1,Bar-Klein Guy5ORCID,Swissa Evyatar1,Hanael Erez6,Ben-Arie Gal7ORCID,Schefenbauer Osnat1,Kamintsky Lyna8,Saar-Ashkenazy Rotem19ORCID,Shelef Ilan7,Shamir Merav H.6,Goldberg Ilan10ORCID,Glik Amir111213,Benninger Felix1113ORCID,Kaufer Daniela23ORCID,Friedman Alon18ORCID

Affiliation:

1. Departments of Physiology and Cell Biology, Cognitive and Brain Sciences, Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.

2. Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA.

3. Department of Integrative Biology, University of California, Berkeley, Berkeley, CA 94720, USA.

4. Berkeley Stem Cell Center, University of California, Berkeley, Berkeley, CA 94720, USA.

5. Howard Hughes Medical Institute and the Institute of Genetic Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA.

6. Koret School of Veterinary Medicine, Hebrew University of Jerusalem, P.O. Box 12, Rehovot 76100, Israel.

7. Department of Medical Imaging, Soroka University Medical Center, Beer-Sheva 84105, Israel.

8. Department of Medical Neuroscience, Dalhousie University, Halifax, NS B3H4R2, Canada.

9. Faculty of Social Work, Ashkelon Academic College, Ashkelon 78211, Israel.

10. Department of Neurology, Wolfson Medical Center, Holon 58100, Israel.

11. Department of Neurology, Rabin Medical Center, Beilinson Hospital, Petach Tikva 49100, Israel.

12. Cognitive Neurology Clinic, Rabin Medical Center, Beilinson Hospital, Petach Tikva 49100, Israel.

13. Sackler School of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.

Abstract

Transient EEG slowing events are shared by patients and models of Alzheimer’s and epilepsy and are associated with blood-brain barrier dysfunction.

Funder

United States - Israel Binational Science Foundation

Israel Science Foundation

European Union

NSF GRFP

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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