A meta-analysis of clinical studies conducted during the West Africa Ebola virus disease outbreak confirms the need for randomized control groups

Author:

Dodd Lori E.12ORCID,Follmann Dean1ORCID,Proschan Michael1ORCID,Wang Jing3,Malvy Denis45,van Griensven Johan6,Ciglenecki Iza7,Horby Peter W.8,Ansumana Rashid910ORCID,Jiang Jia-Fu11ORCID,Davey Richard T.12,Lane H. Clifford13ORCID,Gouel-Cheron Aurelie114

Affiliation:

1. Biostatistics Research Branch, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

2. School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa.

3. Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research Sponsored by the National Cancer Institute, Frederick, MD, USA.

4. Inserm, UMR 1219, Université de Bordeaux, Bordeaux, France.

5. Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France.

6. Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.

7. Operational Centre Geneva, Médecins Sans Frontières, 1211 Geneva, Switzerland.

8. Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK.

9. Mercy Hospital Research Laboratory, Kulanda Town, Bo, Sierra Leone.

10. School of Community Health Sciences, Njala University, Bo, Sierra Leone.

11. Beijing Institute of Microbiology and Epidemiology, Beijing, China.

12. Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

13. Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

14. Anesthesiology and Intensive Care Department, Hopital Bichat—Claude Bernard, Assistance Publique—Hopitaux de Paris, Paris, France.

Abstract

Randomized controlled clinical trials are critical for evaluating new experimental therapeutics to treat Ebola virus disease.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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