Supercharging adoptive T cell therapy to overcome solid tumor–induced immunosuppression

Author:

Mardiana Sherly12ORCID,Solomon Benjamin J.234ORCID,Darcy Phillip K.1256ORCID,Beavis Paul A.12

Affiliation:

1. Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria 3000, Australia.

2. Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria 3010, Australia.

3. Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria 3000, Australia.

4. Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria 3000, Australia.

5. Department of Pathology, University of Melbourne, Parkville, Victoria 3010, Australia.

6. Department of Immunology, Monash University, Clayton, Victoria 3168, Australia.

Abstract

Immune checkpoints can be targeted using exogenous reagents or via genetic modification to enhance the efficacy of adoptive T cell therapy.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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