Apoptosis of hematopoietic progenitor-derived adipose tissue–resident macrophages contributes to insulin resistance after myocardial infarction

Author:

Vasamsetti Sathish Babu1ORCID,Coppin Emilie12ORCID,Zhang Xinyi13ORCID,Florentin Jonathan1,Koul Sasha4,Götberg Matthias4ORCID,Clugston Andrew S.5ORCID,Thoma Floyd6,Sembrat John17ORCID,Bullock Grant C.1ORCID,Kostka Dennis5ORCID,St. Croix Claudette M.8,Chattopadhyay Ansuman9ORCID,Rojas Mauricio17ORCID,Mulukutla Suresh R.6,Dutta Partha1610ORCID

Affiliation:

1. Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA.

2. Regeneration in Hematopoiesis, Leibniz Institute on Aging- Fritz Lipmann Institute, Jena 07745, Germany.

3. The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China.

4. Department of Cardiology, Lund University, Skane University Hospital, Lund, 22184, Sweden.

5. Department of Developmental Biology, University of Pittsburgh, Pittsburgh, PA 15213, USA.

6. Division of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.

7. Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.

8. Department of Cell Biology, University of Pittsburgh, Pittsburgh, PA 15213, USA.

9. Health Sciences Library System, University of Pittsburgh, PA 15213, USA.

10. Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15213, USA.

Abstract

Myocardial infarction promotes insulin resistance via apoptosis of macrophages in visceral adipose tissue.

Funder

National Institutes of Health

American Heart Association

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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