An ocular glymphatic clearance system removes β-amyloid from the rodent eye-Reference-Cited by-同舟云学术

An ocular glymphatic clearance system removes β-amyloid from the rodent eye

Published:2020-03-25 Issue:536 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Wang Xiaowei¹²^ORCID,Lou Nanhong²,Eberhardt Allison²,Yang Yujia³^ORCID,Kusk Peter¹,Xu Qiwu²^ORCID,Förstera Benjamin⁴⁵^ORCID,Peng Sisi²^ORCID,Shi Meng³^ORCID,Ladrón-de-Guevara Antonio²^ORCID,Delle Christine¹^ORCID,Sigurdsson Björn¹^ORCID,Xavier Anna L. R.¹^ORCID,Ertürk Ali⁴⁵,Libby Richard T.⁶^ORCID,Chen Lu³^ORCID,Thrane Alexander S.¹⁷^ORCID,Nedergaard Maiken¹²^ORCID

Affiliation:

1. Center for Translational Neuromedicine, Faculty of Medical and Health Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark.

2. Center for Translational Neuromedicine, University of Rochester Medical School, Elmwood Avenue 601, Rochester, NY 14642, USA.

3. Center for Eye Disease and Development, Vision Science Graduate Program, and School of Optometry, University of California Berkeley, Berkeley, CA 94720, USA.

4. Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig Maximilians University of Munich (LMU), 81377 Munich, Germany.

5. Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Center München, 85764 Munich, Germany.

6. Department of Ophthalmology, University of Rochester Medical Center, Rochester, NY 14642, USA.

7. Department of Ophthalmology, Haukeland University Hospital, Jonas Lies Vei 65, 5021 Bergen, Norway.

Abstract

Glymphatic pathway clears retinal β-amyloid in rodents via optic nerve and is impaired in glaucoma.

Funder

National Institutes of Health

Dr. Miriam and Sheldon G. Adelson Medical Research Foundation

Cure Alzheimer’s Fund

H2020 European Research Council

Lundbeckfonden

Novo Nordisk Fonden