Sparing the region of the salivary gland containing stem cells preserves saliva production after radiotherapy for head and neck cancer

Author:

van Luijk Peter1,Pringle Sarah12,Deasy Joseph O.3,Moiseenko Vitali V.4,Faber Hette12,Hovan Allan5,Baanstra Mirjam12,van der Laan Hans P.1,Kierkels Roel G. J.1,van der Schaaf Arjen1,Witjes Max J.1,Schippers Jacobus M.16,Brandenburg Sytze7,Langendijk Johannes A.1,Wu Jonn5,Coppes Robert P.12

Affiliation:

1. Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, Netherlands.

2. Department of Cell Biology, University Medical Center Groningen, University of Groningen, 9713AV Groningen, Netherlands.

3. Radiation Oncology, Washington University School of Medicine, St. Louis, MO 63110, USA.

4. Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA 92093, USA.

5. British Columbia Cancer Agency–Vancouver Centre, Vancouver, British Columbia V5Z 4E6, Canada.

6. Accelerator Department, Paul Scherrer Institut, CH-5212 Villigen, Switzerland.

7. KVI Center for Advanced Radiation Technology, University of Groningen, 9747 AA Groningen, Netherlands.

Abstract

Avoiding irradiation of the region of the parotid gland containing stem cells reduces the risk of xerostomia (dry mouth).

Funder

ZonMw

Innovational Research Incentives Scheme of the NWO

Dutch Cancer Society

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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