Intratumoral expression of IL-7 and IL-12 using an oncolytic virus increases systemic sensitivity to immune checkpoint blockade-Reference-Cited by-同舟云学术

Intratumoral expression of IL-7 and IL-12 using an oncolytic virus increases systemic sensitivity to immune checkpoint blockade

Published:2020-01-15 Issue:526 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Nakao Shinsuke¹^ORCID,Arai Yukinori¹,Tasaki Mamoru¹,Yamashita Midori¹^ORCID,Murakami Ryuji¹^ORCID,Kawase Tatsuya¹,Amino Nobuaki¹,Nakatake Motomu²,Kurosaki Hajime²,Mori Masamichi¹,Takeuchi Masahiro¹,Nakamura Takafumi²

Affiliation:

1. Drug Discovery Research, Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba 305-8585, Japan.

2. Department of Biomedical Science, Graduate School of Medical Sciences, Tottori University, 86 Nishi-cho, Yonago 683-8503, Japan.

Abstract

Oncolytic vaccinia virus encoding IL-7 and IL-12 facilitates immune checkpoint blockade in treatment-resistant solid tumors.

Funder

Astellas Pharma Inc

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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