PI4KIIIβ is a therapeutic target in chromosome 1q–amplified lung adenocarcinoma

Author:

Tan Xiaochao1ORCID,Banerjee Priyam1ORCID,Pham Edward A.2ORCID,Rutaganira Florentine U. N.3ORCID,Basu Kaustabh2,Bota-Rabassedas Neus1,Guo Hou-Fu1ORCID,Grzeskowiak Caitlin L.45,Liu Xin1,Yu Jiang1,Shi Lei1ORCID,Peng David H.1ORCID,Rodriguez B. Leticia1ORCID,Zhang Jiaqi1ORCID,Zheng Veronica1,Duose Dzifa Y.6,Solis Luisa M.6ORCID,Mino Barbara6ORCID,Raso Maria Gabriela6ORCID,Behrens Carmen6ORCID,Wistuba Ignacio I.6ORCID,Scott Kenneth L.45,Smith Mark27ORCID,Nguyen Khanh2,Lam Grace2ORCID,Choong Ingrid2,Mazumdar Abhijit8,Hill Jamal L.8,Gibbons Don L.1ORCID,Brown Powel H.8ORCID,Russell William K.9ORCID,Shokat Kevan3ORCID,Creighton Chad J.510ORCID,Glenn Jeffrey S.211ORCID,Kurie Jonathan M.1ORCID

Affiliation:

1. Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

2. Departments of Medicine and Microbiology & Immunology, Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA 94305, USA.

3. Howard Hughes Medical Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143, USA.

4. Department of Molecular and Human Genetics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.

5. Department of Medicine, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.

6. Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

7. Stanford ChEM-H Medicinal Chemistry Knowledge Center, Stanford University, CA 94305, USA.

8. Department of Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

9. Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA.

10. Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

11. Veterans Administration Medical Center, Palo Alto, CA 94304, USA.

Abstract

This study identifies a molecular basis for malignant secretion and provides a rationale to test PI4KIIIβ antagonists as an intervention.

Funder

National Institutes of Health

NIH Office of the Director

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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