Gut microbiota dysbiosis and altered tryptophan catabolism contribute to autoimmunity in lupus-susceptible mice-Reference-Cited by-同舟云学术

Gut microbiota dysbiosis and altered tryptophan catabolism contribute to autoimmunity in lupus-susceptible mice

Published:2020-07-08 Issue:551 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Choi Seung-Chul¹^ORCID,Brown Josephine¹^ORCID,Gong Minghao²³^ORCID,Ge Yong²³^ORCID,Zadeh Mojgan²³^ORCID,Li Wei¹^ORCID,Croker Byron P.¹^ORCID,Michailidis George⁴,Garrett Timothy J.¹^ORCID,Mohamadzadeh Mansour²³^ORCID,Morel Laurence¹^ORCID

Affiliation:

1. Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32610, USA.

2. Department of Infectious Diseases and Immunology, University of Florida, Gainesville, FL 32610, USA.

3. Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Florida, Gainesville, FL 32610, USA.

4. Department of Statistics and the Informatics Institute, University of Florida, Gainesville, FL 32610, USA.

Abstract

Gut microbiota dysbiosis induces lupus-like autoimmunity in mice through altered tryptophan catabolism.

Funder

National Institute of Allergy and Infectious Diseases

National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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4. Lupus nephritis is linked to disease-activity associated expansions and immunity to a gut commensal

5. Dynamics of Gut Microbiota in Autoimmune Lupus

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