ROR2 blockade as a therapy for osteoarthritis-Reference-Cited by-同舟云学术

ROR2 blockade as a therapy for osteoarthritis

Published:2020-09-16 Issue:561 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Thorup Anne-Sophie¹^ORCID,Strachan Danielle¹^ORCID,Caxaria Sara¹^ORCID,Poulet Blandine²^ORCID,Thomas Bethan L.¹,Eldridge Suzanne E.¹^ORCID,Nalesso Giovanna³^ORCID,Whiteford James R.¹^ORCID,Pitzalis Costantino¹^ORCID,Aigner Thomas⁴,Corder Roger¹^ORCID,Bertrand Jessica⁵^ORCID,Dell’Accio Francesco¹^ORCID

Affiliation:

1. William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.

2. Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool L7 8TX, UK.

3. Department of Veterinary Preclinical Sciences, School of Veterinary Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7AL, UK.

4. Institute of Pathology, Medical Center Coburg, Ketschendorferstrasse 33, 96450 Coburg, Germany.

5. Department of Orthopaedic Surgery, Otto-von-Guericke University, 39120 Magdeburg, Germany.

Abstract

ROR2 blockade improves the functional and structural outcomes of osteoarthritis in preclinical animal models by inhibiting YAP signaling.

Funder

Medical Research Council

Deutsche Forschungsgemeinschaft

Versus Arthritis

William Harvey Research Foundation

FOREUM

Medical College of St Bartholomew’s Hospital Trust

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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