PBX1 expression in uterine natural killer cells drives fetal growth

Author:

Zhou Yonggang123ORCID,Fu Binqing12ORCID,Xu Xiuxiu12,Zhang Jinghe12,Tong Xianhong3,Wang Yanshi3,Dong Zhongjun4,Zhang Xiaoren5,Shen Nan6ORCID,Zhai Yiwen7ORCID,Kong Xiangdong7ORCID,Sun Rui12,Tian Zhigang12ORCID,Wei Haiming12ORCID

Affiliation:

1. Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China.

2. Institute of Immunology, University of Science and Technology of China, Hefei, Anhui 230027, China.

3. First Affiliated Hospital, University of Science and Technology of China, Hefei, Anhui 230026, China.

4. School of Medicine, Tsinghua University, Beijing 100086, China.

5. CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200025, China.

6. Shanghai Institute of Rheumatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200001, China.

7. Center for Genetic and Prenatal Diagnosis, Department of Gynecology and Obstetrics, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.

Abstract

A subset of uterine natural killer cells promotes fetal growth through regulation of growth-promoting factors by PBX1.

Funder

National Natural Science Foundation of China

China Postdoctoral Science Foundation

National key R&D program of China

Anhui Provincial Natural Science Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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