Commensal orthologs of the human autoantigen Ro60 as triggers of autoimmunity in lupus-Reference-Cited by-同舟云学术

Commensal orthologs of the human autoantigen Ro60 as triggers of autoimmunity in lupus

Published:2018-03-28 Issue:434 Volume:10 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Greiling Teri M.¹²^ORCID,Dehner Carina¹^ORCID,Chen Xinguo³⁴^ORCID,Hughes Kevin³⁴^ORCID,Iñiguez Alonso J.¹^ORCID,Boccitto Marco³⁴^ORCID,Ruiz Daniel Zegarra¹^ORCID,Renfroe Stephen C.¹^ORCID,Vieira Silvio M.¹^ORCID,Ruff William E.¹^ORCID,Sim Soyeong³⁴^ORCID,Kriegel Christina¹,Glanternik Julia¹^ORCID,Chen Xindi¹^ORCID,Girardi Michael²,Degnan Patrick⁵,Costenbader Karen H.⁶^ORCID,Goodman Andrew L.⁵^ORCID,Wolin Sandra L.³⁴^ORCID,Kriegel Martin A.¹⁷^ORCID

Affiliation:

1. Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA.

2. Department of Dermatology, Yale University School of Medicine, New Haven, CT 06510, USA.

3. Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06510, USA.

4. RNA Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.

5. Department of Microbial Pathogenesis and Yale Microbial Sciences Institute, Yale University School of Medicine, New Haven, CT 06510, USA.

6. Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.

7. Section of Rheumatology, Department of Medicine, Yale University School of Medicine, New Haven, CT 06510, USA.

Abstract

Commensal bacterial orthologs of the human autoantigen Ro60 may trigger cross-reactive T and B cells that initiate and sustain chronic autoimmunity in lupus.

Funder

National Science Foundation

National Institutes of Health

Ruth L. Kirschstein National Research Service Award

National Center for Research Resources

Arthritis National Research Foundation

Arthritis Foundation

Lupus Research Institute

National Center for Advancing Translational Sciences

Women’s Health Research at Yale

Publisher

American Association for the Advancement of Science (AAAS)