RNAi-based treatment of chronically infected patients and chimpanzees reveals that integrated hepatitis B virus DNA is a source of HBsAg-Reference-Cited by-同舟云学术

RNAi-based treatment of chronically infected patients and chimpanzees reveals that integrated hepatitis B virus DNA is a source of HBsAg

Published:2017-09-27 Issue:409 Volume:9 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Wooddell Christine I.¹^ORCID,Yuen Man-Fung²,Chan Henry Lik-Yuen³,Gish Robert G.⁴,Locarnini Stephen A.⁵⁶,Chavez Deborah⁷^ORCID,Ferrari Carlo⁸⁹,Given Bruce D.¹^ORCID,Hamilton James¹⁰^ORCID,Kanner Steven B.¹,Lai Ching-Lung²,Lau Johnson Y. N.¹¹^ORCID,Schluep Thomas¹⁰^ORCID,Xu Zhao¹,Lanford Robert E.⁷,Lewis David L.¹

Affiliation:

1. Arrowhead Pharmaceuticals, 502 South Rosa Road, Madison, WI 53719, USA.

2. Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China.

3. Department of Medicine and Therapeutics and Institute of Digestive Disease, Chinese University of Hong Kong, Hong Kong, China.

4. Liver Transplant Program, Stanford University Medical Center, San Diego, CA 92037, USA.

5. Victorian Infectious Diseases Reference Laboratory, Melbourne, Victoria 3000, Australia.

6. WHO Regional Reference Laboratory for Hepatitis B, Doherty Institute, Melbourne, Victoria, Australia.

7. Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78227, USA.

8. Unit of Infectious Diseases and Hepatology, University of Parma, Parma 43126, Italy.

9. Azienda Ospedaliero-Universitaria of Parma, Parma 43126, Italy.

10. Arrowhead Pharmaceuticals, 225 South Lake Avenue, Suite 1050, Pasadena, CA 91101, USA.

11. Hong Kong Polytechnic University, Hong Kong, China.

Abstract

The hepatitis B virus surface antigen, key to maintaining chronic infection, is expressed from viral DNA integrated into the host chromosome.

Funder

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference39 articles.

1. Global, regional, and national age–sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013

2. Chronic Hepatitis B Virus Infection

3. HEPATOCELLULAR CARCINOMA AND HEPATITIS B VIRUS

4. Structural organization of the hepatitis B virus minichromosome

5. The effects of hepatitis B virus integration into the genomes of hepatocellular carcinoma patients

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