Lung and gut microbiota are altered by hyperoxia and contribute to oxygen-induced lung injury in mice

Author:

Ashley Shanna L.1ORCID,Sjoding Michael W.123,Popova Antonia P.4ORCID,Cui Tracy X.4ORCID,Hoostal Matthew J.5ORCID,Schmidt Thomas M.56,Branton William R.1ORCID,Dieterle Michael G.56ORCID,Falkowski Nicole R.1,Baker Jennifer M.16ORCID,Hinkle Kevin J.1ORCID,Konopka Kristine E.7,Erb-Downward John R.1ORCID,Huffnagle Gary B.1689,Dickson Robert P.136ORCID

Affiliation:

1. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.

2. Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI, USA.

3. Michigan Center for Integrative Research in Critical Care, Ann Arbor, MI, USA.

4. Division of Pediatric Pulmonology, Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, USA.

5. Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.

6. Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, USA.

7. Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.

8. Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.

9. Mary H. Weiser Food Allergy Center, University of Michigan, Ann Arbor, MI, USA.

Abstract

Inhaled oxygen alters the microbiota of mice and humans, which may contribute to oxygen-induced lung injury.

Funder

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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