Reprogrammed marrow adipocytes contribute to myeloma-induced bone disease

Author:

Liu Huan1ORCID,He Jin1,Koh Su Pin2ORCID,Zhong Yuping3,Liu Zhiqiang14ORCID,Wang Zhiqiang1,Zhang Yujin1,Li Zongwei1,Tam Bjorn T.1ORCID,Lin Pei5,Xiao Min5ORCID,Young Ken H.5,Amini Behrang6ORCID,Starbuck Michael W.7,Lee Hans C.1,Navone Nora M.7ORCID,Davis Richard E.1ORCID,Tong Qiang8ORCID,Bergsagel P. Leif9ORCID,Hou Jian10,Yi Qing11ORCID,Orlowski Robert Z.1,Gagel Robert F.12ORCID,Yang Jing1ORCID

Affiliation:

1. Department of Lymphoma and Myeloma, Center for Cancer Immunology Research, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

2. Department of Biochemistry and Molecular Biology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.

3. Department of Hematology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, People’s Republic of China.

4. Department of Pathophysiology, Tianjin Medical University, Tianjin, People’s Republic of China.

5. Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

6. Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA

7. Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

8. USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.

9. Division of Hematology and Medical Oncology, Mayo Clinic, Scottsdale, AZ 85259, USA.

10. Department of Hematology, Renji Hospital, Shanghai Jiaotong University School of Medicine, 160 Pujian Rd, Shanghai, People’s Republic of China.

11. Cancer Center for Hematological Malignancies, Houston Methodist Hospital, Houston, TX 77030, USA.

12. Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Abstract

Marrow adipocytes reprogrammed by myeloma cells induce bone lesions.

Funder

American Cancer Society

National Cancer Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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