Selective YAP/TAZ inhibition in fibroblasts via dopamine receptor D1 agonism reverses fibrosis-Reference-Cited by-同舟云学术

Selective YAP/TAZ inhibition in fibroblasts via dopamine receptor D1 agonism reverses fibrosis

Published:2019-10-30 Issue:516 Volume:11 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Haak Andrew J.¹^ORCID,Kostallari Enis²^ORCID,Sicard Delphine¹,Ligresti Giovanni¹^ORCID,Choi Kyoung Moo¹^ORCID,Caporarello Nunzia¹,Jones Dakota L.¹,Tan Qi¹,Meridew Jeffrey¹,Diaz Espinosa Ana M.¹^ORCID,Aravamudhan Aja¹,Maiers Jessica L.²,Britt Rodney D.¹³⁴^ORCID,Roden Anja C.⁵^ORCID,Pabelick Christina M.¹³^ORCID,Prakash Y. S.¹³^ORCID,Nouraie Seyed Mehdi⁶^ORCID,Li Xiaoyun⁶^ORCID,Zhang Yingze⁶^ORCID,Kass Daniel J.⁶,Lagares David⁷^ORCID,Tager Andrew M.⁷,Varelas Xaralabos⁸^ORCID,Shah Vijay H.²^ORCID,Tschumperlin Daniel J.¹^ORCID

Affiliation:

1. Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.

2. Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA.

3. Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester MN 55905, USA.

4. Abigail Wexner Research Institute at Nationwide Children's Hospital and Department of Pediatrics, Ohio State University, Columbus, OH 43215, USA.

5. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester MN 55905, USA.

6. Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease and Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.

7. Division of Pulmonary and Critical Care Medicine, Fibrosis Research Center, and Center for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

8. Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA.

Abstract

Pharmacologic stimulation of a G protein–coupled receptor preferentially expressed on fibroblasts reverses experimental lung and liver fibrosis.

Funder

National Heart, Lung, and Blood Institute

American Liver Foundation

American Thoracic Society

Scleroderma Research Foundation

American Lung Association

Scleroderma Foundation

American Association for the Study of Liver Diseases

Publisher