Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition

Author:

Habets Roger A.12ORCID,de Bock Charles E.345ORCID,Serneels Lutgarde12ORCID,Lodewijckx Inge34,Verbeke Delphine34ORCID,Nittner David67ORCID,Narlawar Rajeshwar12ORCID,Demeyer Sofie34ORCID,Dooley James28ORCID,Liston Adrian28ORCID,Taghon Tom910ORCID,Cools Jan34ORCID,de Strooper Bart1211ORCID

Affiliation:

1. Department of Neurosciences, Leuven Institute for Neuroscience and Disease (LIND), KU Leuven, 3000 Leuven, Belgium.

2. VIB Center for Brain and Disease Research, VIB, 3000 Leuven, Belgium.

3. Center for Human Genetics, KU Leuven, 3000 Leuven, Belgium.

4. VIB Center for Cancer Biology, VIB, 3000 Leuven, Belgium.

5. Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Sydney, NSW 2052, Australia.

6. Histopathology Expertise Center, VIB-KU Leuven Center for Cancer Biology, 3000 Leuven, Belgium.

7. Department of Oncology, KU Leuven, 3000 Leuven, Belgium.

8. Department of Microbiology and Immunology, KU Leuven, 3000 Leuven, Belgium.

9. Department of Diagnostic Sciences, Faculty of Medicine and Health Sciences, Ghent University, 9000 Ghent, Belgium.

10. Cancer Research Institute Ghent, 9000 Ghent, Belgium.

11. Dementia Research Institute, University College London, London WC1E 6BT, UK.

Abstract

Selective inhibition of γ-secretase complexes targets T-ALL without the dose-limiting side effects of complete γ-secretase inhibition.

Funder

Stand Up To Cancer

European Research Council

Vlaamse Overheid

Fonds Wetenschappelijk Onderzoek

KU Leuven

Vlaams Instituut voor Biotechnologie

Bax-Vanluffelen Chair for Alzheimer’s Disease

Leuven Universiteit Fonds

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Cited by 81 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3