Filamentous bacteriophages are associated with chronic Pseudomonas lung infections and antibiotic resistance in cystic fibrosis

Author:

Burgener Elizabeth B.1ORCID,Sweere Johanna M.23ORCID,Bach Michelle S.2ORCID,Secor Patrick R.4ORCID,Haddock Naomi3ORCID,Jennings Laura K.4ORCID,Marvig Rasmus L.5ORCID,Johansen Helle Krogh67ORCID,Rossi Elio6ORCID,Cao Xiou2ORCID,Tian Lu8,Nedelec Laurence9,Molin Søren9ORCID,Bollyky Paul L.23ORCID,Milla Carlos E.1

Affiliation:

1. Center for Excellence in Pulmonary Biology, Department of Pediatrics, Stanford University, Stanford, CA 94305, USA.

2. Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University, Stanford, CA 94305, USA.

3. Stanford Immunology, Stanford University, Stanford, CA 94305, USA.

4. Division of Biological Sciences, University of Montana, Missoula, MT 59812, USA.

5. Center for Genomic Medicine, Rigshospitalet–Copenhagen University Hospital, Copenhagen, Denmark.

6. Department of Clinical Microbiology, Rigshospitalet, Copenhagen Ø, Denmark.

7. Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen N, Denmark.

8. Biomedical Data Science Administration and Statistics, Stanford University, Stanford, CA 94305, USA.

9. Primary Care and Population Health, Stanford University, Stanford, CA 94305, USA.

Abstract

Pseudomonas strains that produce filamentous bacteriophage are associated with chronic infection and increased antibiotic resistance in patients with cystic fibrosis.

Funder

National Institutes of Health

Cystic Fibrosis Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference58 articles.

1. Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA

2. M. J. Welsh B. W. Ramsey F. Accurso G. R. Cutting in The Online Metabolic and Molecular Bases of Inherited Disease A. L. Beaudet B. Vogelstein K. W. Kinzler S. E. Antonarakis A. Ballabio K. M. Gibson G. Mitchell Eds. (The McGraw-Hill Companies Inc. 2014).

3. Bicarbonate conductance and pH regulatory capability of cystic fibrosis transmembrane conductance regulator.

4. Early pulmonary inflammation in infants with cystic fibrosis;Khan T. Z.;Am. J. Respir. Crit. Care Med.,1995

5. Cystic fibrosis.

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