Noncoding regions are the main source of targetable tumor-specific antigens-Reference-Cited by-同舟云学术

Noncoding regions are the main source of targetable tumor-specific antigens

Published:2018-12-05 Issue:470 Volume:10 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Laumont Céline M.¹²^ORCID,Vincent Krystel¹²^ORCID,Hesnard Leslie¹²^ORCID,Audemard Éric¹^ORCID,Bonneil Éric¹^ORCID,Laverdure Jean-Philippe¹^ORCID,Gendron Patrick¹^ORCID,Courcelles Mathieu¹^ORCID,Hardy Marie-Pierre¹,Côté Caroline¹^ORCID,Durette Chantal¹,St-Pierre Charles¹²,Benhammadi Mohamed¹²^ORCID,Lanoix Joël¹,Vobecky Suzanne³^ORCID,Haddad Elie³^ORCID,Lemieux Sébastien¹⁴^ORCID,Thibault Pierre¹⁵^ORCID,Perreault Claude¹²^ORCID

Affiliation:

1. Institute for Research in Immunology and Cancer (IRIC), Université de Montréal, Montreal, Quebec H3C 3J7, Canada.

2. Department of Medicine, Université de Montréal, Montreal, Quebec H3C 3J7, Canada.

3. CHU Sainte-Justine, Université de Montréal, Montreal, Quebec H3T 1C5, Canada.

4. Department of Computer Science and Operations Research, Université de Montréal, Montreal, Quebec H3C 3J7, Canada.

5. Department of Chemistry, Université de Montréal, Montreal, Quebec H3C 3J7, Canada.

Abstract

A proteogenomic method identifies potentially actionable tumor-specific antigens and shows that most of them are not coded by classic exons.

Funder

Canadian Cancer Society

Terry Fox Research Institute

Quebec Breast Cancer Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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