An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice-Reference-Cited by-同舟云学术

An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice

Published:2020-04-29 Issue:541 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Sheahan Timothy P.¹^ORCID,Sims Amy C.¹^ORCID,Zhou Shuntai²^ORCID,Graham Rachel L.¹^ORCID,Pruijssers Andrea J.³^ORCID,Agostini Maria L.³,Leist Sarah R.¹^ORCID,Schäfer Alexandra¹^ORCID,Dinnon Kenneth H.¹⁴^ORCID,Stevens Laura J.³^ORCID,Chappell James D.³,Lu Xiaotao³^ORCID,Hughes Tia M.³^ORCID,George Amelia S.³^ORCID,Hill Collin S.²^ORCID,Montgomery Stephanie A.⁵^ORCID,Brown Ariane J.¹,Bluemling Gregory R.⁶⁷^ORCID,Natchus Michael G.⁶,Saindane Manohar⁶,Kolykhalov Alexander A.⁶⁷,Painter George⁶⁷⁸^ORCID,Harcourt Jennifer⁹^ORCID,Tamin Azaibi⁹^ORCID,Thornburg Natalie J.⁹,Swanstrom Ronald²¹⁰^ORCID,Denison Mark R.³^ORCID,Baric Ralph S.¹⁴^ORCID

Affiliation:

1. Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

2. Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

3. Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

4. Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

5. Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.

6. Emory Institute of Drug Development (EIDD), Emory University, Atlanta, GA 30322, USA.

7. Drug Innovation Ventures at Emory (DRIVE), Atlanta, GA 30322, USA.

8. Department of Pharmacology and Chemical Biology, Emory University, Atlanta, GA 30322, USA.

9. Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.

10. Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Abstract

A ribonucleoside analog inhibits SARS-CoV-2 in human airway epithelial cell cultures and SARS-CoV and MERS-CoV in mice.

Funder

National Institute of Allergy and Infectious Diseases

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference65 articles.

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2. SARS and MERS: recent insights into emerging coronaviruses

3. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China

4. Further Evidence for Bats as the Evolutionary Source of Middle East Respiratory Syndrome Coronavirus

5. Bat origin of human coronaviruses

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