Eosinophils attenuate hepatic ischemia-reperfusion injury in mice through ST2-dependent IL-13 production

Author:

Wang Yaochun12ORCID,Yang Yang1ORCID,Wang Meng1ORCID,Wang Shuhong1ORCID,Jeong Jong-Min1,Xu Long1,Wen Yankai1ORCID,Emontzpohl Christoph1ORCID,Atkins Constance Lynn1ORCID,Duong Kevin1ORCID,Moreno Nicolas F.1,Yuan Xiaoyi1ORCID,Hall David R.3ORCID,Dar Wasim3ORCID,Feng Dechun4ORCID,Gao Bin4,Xu Yong56ORCID,Czigany Zoltan7ORCID,Colgan Sean P.8ORCID,Bynon J. Steve3ORCID,Akira Shizuo9,Brown Jared M.10,Eltzschig Holger K.1,Jacobsen Elizabeth A.11ORCID,Ju Cynthia1ORCID

Affiliation:

1. Department of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.

2. Center for Translational Medicine, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China.

3. Department of Surgery, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.

4. Laboratory of Liver Disease, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD 20892, USA.

5. Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.

6. Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.

7. Department of Surgery and Transplantation, Faculty of Medicine, University Hospital RWTH Aachen, Aachen 52074, Germany.

8. Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.

9. Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan.

10. School of Pharmacy, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.

11. Division of Allergy, Asthma and Clinical Immunology, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA.

Abstract

Eosinophils protect against liver injury during orthotopic liver transplantation and other conditions of hepatic ischemia-reperfusion injury in mice.

Funder

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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