A self-amplifying loop of YAP and SHH drives formation and expansion of heterotopic ossification-Reference-Cited by-同舟云学术

A self-amplifying loop of YAP and SHH drives formation and expansion of heterotopic ossification

Published:2021-06-23 Issue:599 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Cong Qian¹^ORCID,Liu Yuchen¹,Zhou Taifeng¹^ORCID,Zhou Yaxing¹,Xu Ruoshi¹,Cheng Caiqi¹,Chung Hye Soo¹^ORCID,Yan Meijun²,Zhou Hang²,Liao Zhiheng³,Gao Bo¹,Bocobo Geoffrey A.²^ORCID,Covington Taylor A.²^ORCID,Song Hyeon Ju²^ORCID,Su Peiqiang³,Yu Paul B.²^ORCID,Yang Yingzi¹^ORCID

Affiliation:

1. Department of Developmental Biology, Harvard School of Dental Medicine, Harvard Stem Cell Institute, 188 Longwood Ave., Boston, MA 02115, USA.

2. Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.

3. Department of Orthopaedic Surgery, Guangdong Provincial Key Laboratory of Orthopedics and Traumatology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.

Abstract

A self-amplifying and propagating loop of YAP-SHH is a core molecular mechanism underlying diverse forms of heterotopic ossification.

Funder

National Cancer Institute

National Institute of Arthritis and Musculoskeletal and Skin Diseases

National Institute of Dental and Craniofacial Research

National Natural Science Foundation of China

Orphan disease center at the University of Pennsylvania

China Scholarship Council of the Chinese Ministry of Education.

International Fibrodysplasia Ossificans Progressiva Research Award

Publisher

American Association for the Advancement of Science (AAAS)