Radiotherapy and immunotherapy converge on elimination of tumor-promoting erythroid progenitor cells through adaptive immunity-Reference-Cited by-同舟云学术

Radiotherapy and immunotherapy converge on elimination of tumor-promoting erythroid progenitor cells through adaptive immunity

Published:2021-02-24 Issue:582 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Hou Yuzhu¹²^ORCID,Liang Hua L.²^ORCID,Yu Xinshuang³^ORCID,Liu Zhida⁴^ORCID,Cao Xuezhi⁴^ORCID,Rao Enyu⁵,Huang Xiaona²,Wang Liangliang²^ORCID,Li Lei²,Bugno Jason⁶^ORCID,Fu Yanbin²,Chmura Steven J.²^ORCID,Wu Wenjun⁷,Luo Sean Z.⁸,Zheng Wenxin²,Arina Ainhoa²^ORCID,Jutzy Jessica²^ORCID,McCall Anne R.⁹^ORCID,Vokes Everett E.¹⁰^ORCID,Pitroda Sean P.²,Fu Yang-Xin⁴^ORCID,Weichselbaum Ralph R.²^ORCID

Affiliation:

1. Department of Pathogenic Microbiology and Immunology, School of Basic Medical Sciences, Xi’an Jiaotong University, Xi’an, ShaanXi 710061, China.

2. Ludwig Center for Metastasis Research, Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL 60637 USA.

3. Department of Oncology, First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, Shandong 250014, China.

4. Department of Pathology, University of Texas Southwest Medical Center, Dallas, TX 75235, USA.

5. Cancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China.

6. Committee on Clinical Pharmacology and Pharmacogenomics, University of Chicago, Chicago, IL 60637, USA.

7. Fox Chase Cancer Center, Philadelphia, PA 19111, USA.

8. Whitney Young High School, Chicago, IL 60607, USA.

9. Radiation and Cellular Oncology, University of Chicago, Chicago, IL 60637, USA.

10. Department of Medicine, University of Chicago, Chicago, IL 60637, USA.

Abstract

Radiation and immunotherapy reduce tumor-induced erythroid progenitor cells, revealing possible targets for potentiating cancer therapies.

Funder

National Institutes of Health

Ludwig Institute for Cancer Research