Inhibition of the alternative complement pathway preserves photoreceptors after retinal injury-Reference-Cited by-同舟云学术

Inhibition of the alternative complement pathway preserves photoreceptors after retinal injury

Published:2015-07-22 Issue:297 Volume:7 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Sweigard J. Harry¹,Matsumoto Hidetaka¹,Smith Kaylee E.¹,Kim Leo A.²,Paschalis Eleftherios I.²,Okonuki Yoko¹,Castillejos Alexandra¹,Kataoka Keiko¹,Hasegawa Eiichi¹,Yanai Ryoji¹,Husain Deeba¹,Lambris John D.³,Vavvas Demetrios¹,Miller Joan W.¹,Connor Kip M.¹

Affiliation:

1. Angiogenesis Laboratory, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA.

2. Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA.

3. Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Abstract

The alternative complement pathway is activated in response to retinal injury, and inhibiting this pathway prevents complement-mediated photoreceptor cell death.

Funder

NIH

March of Dimes Foundation

Research to Prevent Blindness

Massachusetts Lions Eye Research Fund Inc.

Howe Laboratory endowment of the Massachusetts Eye and Ear Infirmary

RPB Physician-Scientist Award

Yeatts Family Foundation

The Loeffler Family fund

2013 Macula Society Research

Japan Eye Bank Association

Publisher