The prodrug DHED selectively delivers 17β-estradiol to the brain for treating estrogen-responsive disorders-Reference-Cited by-同舟云学术

The prodrug DHED selectively delivers 17β-estradiol to the brain for treating estrogen-responsive disorders

Published:2015-07-22 Issue:297 Volume:7 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Prokai Laszlo¹²,Nguyen Vien¹,Szarka Szabolcs¹,Garg Puja¹³,Sabnis Gauri⁴,Bimonte-Nelson Heather A.⁵⁶,McLaughlin Katie J.⁵,Talboom Joshua S.⁵⁶,Conrad Cheryl D.⁵,Shughrue Paul J.⁷,Gould Todd D.⁴⁸⁹,Brodie Angela⁴,Merchenthaler Istvan⁹¹⁰,Koulen Peter³,Prokai-Tatrai Katalin¹²

Affiliation:

1. Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.

2. AgyPharma LLC, Mansfield, TX 76063, USA.

3. Vision Research Center and Departments of Ophthalmology and Basic Medical Science, University of Missouri–Kansas City, School of Medicine, Kansas City, MO 64108, USA.

4. Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

5. Department of Psychology, Arizona State University, Tempe, AZ 85287, USA.

6. Arizona Alzheimer’s Consortium, Tempe, AZ 85014, USA.

7. Department of Pharmacology, Elan Pharmaceuticals Inc., South San Francisco, CA 94080, USA.

8. Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

9. Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

10. Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

Abstract

The bioprecursor prodrug 10β, 17β-dihydroxyestra-1,4-dien-3-one (DHED) allows 17β-estradiol to form in the female brain for neuroprotection and to treat neurological and psychiatric symptoms of menopause.

Funder

NIH

Robert A. Welch Foundation

Felix and Carmen Sabates Missouri Endowed Chair in Vision Research

Vision Research Foundation of Kansas City

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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