Blood-brain barrier–penetrating siRNA nanomedicine for Alzheimer’s disease therapy-Reference-Cited by-同舟云学术

Blood-brain barrier–penetrating siRNA nanomedicine for Alzheimer’s disease therapy

Published:2020-10-09 Issue:41 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Zhou Yutong¹^ORCID,Zhu Feiyan²^ORCID,Liu Yang²³^ORCID,Zheng Meng²^ORCID,Wang Yibin²^ORCID,Zhang Dongya²^ORCID,Anraku Yasutaka⁴,Zou Yan²⁵,Li Jia³^ORCID,Wu Haigang²^ORCID,Pang Xiaobin³,Tao Wei⁶^ORCID,Shimoni Olga⁷^ORCID,Bush Ashley I.⁸^ORCID,Xue Xue¹^ORCID,Shi Bingyang²⁵^ORCID

Affiliation:

1. State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin 300350, China.

2. Henan-Macquarie Uni Joint Centre for Biomedical Innovation, School of Life Sciences, Henan University, Kaifeng, Henan 475004, China.

3. School of Pharmacy, Henan University, Kaifeng, Henan 475004, China.

4. Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.

5. Department of Biomedical Sciences, Faculty of Medicine & Health Sciences, Macquarie University, Sydney, NSW 2109, Australia.

6. Center for Nanomedicine and Department of Anesthesiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

7. Institute for Biomedical Materials & Devices (IBMD), School of Mathematical and Physical Sciences, University of Technology Sydney, 15 Broadway, Ultimo, NSW 2007, Australia.

8. Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC 3010, Australia.

Abstract

Glycosylated “triple-interaction” stabilized siRNA nanomedicine ameliorated AD neuropathology by targeting BACE1.

Funder

National Natural Science Foundation of China

National Key Technologies R&D Program of China

the Key Research Program in Colleges and Universities of Henan Province

Australian Endeavour Fellowship

Mason Foundation National Medical Program

National Health and Medical Research Council (NHMRC) Dementia Fellowship

National Health and Medical Research Council (NHMRC) Project Grant

Publisher