Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer’s disease-Reference-Cited by-同舟云学术

Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer’s disease

Published:2020-12-04 Issue:49 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Zhang Xinwen¹^ORCID,Wang Rihua¹,Hu Di¹^ORCID,Sun Xiaoyan¹,Fujioka Hisashi²,Lundberg Kathleen³^ORCID,Chan Ernest R.⁴^ORCID,Wang Quanqiu⁴,Xu Rong⁴,Flanagan Margaret E.⁵⁶,Pieper Andrew A.⁷⁸,Qi Xin¹^ORCID

Affiliation:

1. Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.

2. Electron Microscopy Core Facility, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.

3. Center for Proteomics and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.

4. Center for Artificial Intelligence in Drug Discovery, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.

5. Mesulam Center for Cognitive Neurology and Alzheimer’s Disease Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

6. Department of Pathology, Northwestern University, Chicago, IL 60611, USA.

7. Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA.

8. Department of Psychiatry Case Western Reserve University, Geriatric Research Education and Clinical Centers, Louis Stokes Cleveland VAMC, Cleveland, OH 44106, USA.

Abstract

The Drp1-HK1-NLRP3 axis is a key mechanism of oligodendrocyte damage and white matter degeneration in AD.

Funder

Dr. Ralph and Marian Falk Medical Research Foundation Transformative Award

Pilot fund from Department of Physiology and Biophysics, Case Western Reserve University

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference60 articles.

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