Phagocytosis of Wnt inhibitor SFRP4 by late wound macrophages drives chronic Wnt activity for fibrotic skin healing

Author:

Gay Denise12ORCID,Ghinatti Giulia1234ORCID,Guerrero-Juarez Christian F.5ORCID,Ferrer Rubén A.6,Ferri Federica1234,Lim Chae Ho7,Murakami Shohei1234,Gault Nathalie1234ORCID,Barroca Vilma1234,Rombeau Isabelle8,Mauffrey Philippe123,Irbah Lamya123,Treffeisen Elsa9ORCID,Franz Sandra610ORCID,Boissonnas Alexandre11,Combadière Christophe11,Ito Mayumi7,Plikus Maksim V.5ORCID,Romeo Paul-Henri1234ORCID

Affiliation:

1. CEA/DRF/IBFJ/iRCM/LRTS, 92265 Fontenay-aux-Roses cedex, France.

2. Inserm U1074, 92265 Fontenay-aux-Roses cedex, France.

3. Université Paris-Diderot, Paris 7, France.

4. Université Paris-Sud, Paris 11, France.

5. Department of Developmental and Cell Biology, Sue and Bill Gross Stem Cell Research Center, NSF-Simons Center for Multiscale Cell Fate Research, Center for Complex Biological Systems, University of California, Irvine, Irvine, CA 92697, USA.

6. Department of Dermatology, University Leipzig Medical Center, Leipzig, Germany.

7. Ronald O. Perelman Department of Dermatology and Cell Biology, School of Medicine, New York University, New York, NY 10016, USA.

8. Charles River Laboratories, 169 Bois des Oncins, 69210 Saint-Germain-Nuelles, France.

9. Department of Pediatrics, Cohen Children's Medical Center Northwell Health, New Hyde Park, NY 11040, USA.

10. DFG-German Research Council Transregio 67, Leipzig-Dresden, Germany.

11. Sorbonne Université, Inserm, CNRS, Centre d’Immunologie et des Maladies Infectieuses, Cimi-Paris, F-75013, Paris, France.

Abstract

Macrophages, renowned for clearance of debris and bacteria in the wound, can also uptake signaling inhibitors to promote fibrosis.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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