Multiple screening approaches reveal HDAC6 as a novel regulator of glycolytic metabolism in triple-negative breast cancer-Reference-Cited by-同舟云学术

Multiple screening approaches reveal HDAC6 as a novel regulator of glycolytic metabolism in triple-negative breast cancer

Published:2021-01-15 Issue:3 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Dowling Catríona M.¹²^ORCID,Hollinshead Kate E. R.³,Di Grande Alessandra¹,Pritchard Justin⁴,Zhang Hua²,Dillon Eugene T.⁵,Haley Kathryn¹^ORCID,Papadopoulos Eleni²^ORCID,Mehta Anita K.⁶^ORCID,Bleach Rachel¹^ORCID,Lindner Andreas U.¹^ORCID,Mooney Brian⁷,Düssmann Heiko¹^ORCID,O’Connor Darran⁷,Prehn Jochen H. M.¹,Wynne Kieran⁵^ORCID,Hemann Michael⁸^ORCID,Bradner James E.⁶^ORCID,Kimmelman Alec C.³,Guerriero Jennifer L.⁶^ORCID,Cagney Gerard⁵^ORCID,Wong Kwok-Kin²,Letai Anthony G.⁶^ORCID,Chonghaile Tríona Ní¹^ORCID

Affiliation:

1. Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland.

2. Division of Hematology and Medical Oncology, Laura and Isaac Perlmutter Cancer Center, New York University Langone Medical Center, New York, NY, USA.

3. Department of Radiation Oncology, Laura and Isaac Perlmutter Cancer Center, New York University Langone Medical Center, New York, NY, USA.

4. Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA, USA.

5. School of Biomolecular and Biomedical Science, Conway Institute of Biomedical and Biomolecular Sciences, University College Dublin, Dublin, Ireland.

6. Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

7. Department of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.

8. Koch Institute for Integrative Cancer Research at MIT, Massachusetts Institute of Technology, Cambridge, MA, USA.

Abstract

Discovery of a new HDAC6 inhibitor reveals role for HDAC6 in the regulation of glycolytic metabolism.

Funder

Breast Cancer Now

Wellcome

H2020 Marie Skłodowska-Curie Actions

Irish Research Council for Science, Engineering and Technology

Science Foundation Ireland

Publisher