Myeloid Tribbles 1 induces early atherosclerosis via enhanced foam cell expansion

Author:

Johnston Jessica M.1ORCID,Angyal Adrienn1ORCID,Bauer Robert C.23ORCID,Hamby Stephen4,Suvarna S. Kim1,Baidžajevas Kajus1ORCID,Hegedus Zoltan56,Dear T. Neil7,Turner Martin8ORCID,Wilson Heather L.1ORCID,Goodall Alison H.4ORCID,Rader Daniel J.3ORCID,Shoulders Carol C.9ORCID,Francis Sheila E.1ORCID,Kiss-Toth Endre1ORCID,

Affiliation:

1. Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, UK.

2. Division of Cardiology, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA.

3. Perelman School of Medicine at the University of Pennsylvania and Children’s Hospital of Philadelphia, Philadelphia, PA 19104-5158, USA.

4. Department of Cardiovascular Sciences, University of Leicester and NIHR Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, UK.

5. Institute of Biophysics, Biological Research Centre, Hungarian Academy of Sciences, Temesvari korut 62, Szeged H-6726, Hungary.

6. Departments of Biochemistry and Medical Chemistry, University of Pecs, Medical School, Szigeti ut 12, Pecs H-7624, Hungary.

7. Division of Biomedical Services, University of Leicester, Leicester, UK.

8. Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK.

9. Centre for Endocrinology, William Harvey Research Institute, Queen Mary University of London and the Barts and the London School of Medicine and Dentistry, London EC1M 6BQ, UK.

Abstract

Trib1 controls atherosclerotic plaque macrophage function by up-regulating OLR1, promoting foam cell formation and atherosclerosis.

Funder

Biotechnology and Biological Sciences Research Council

British Heart Foundation

European Commission

Fondation Leducq

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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