Exosome-based delivery of super-repressor IκBα relieves sepsis-associated organ damage and mortality

Author:

Choi Hojun12ORCID,Kim Youngeun3ORCID,Mirzaaghasi Amin1ORCID,Heo Jaenyoung3ORCID,Kim Yu Na3,Shin Ju Hye4ORCID,Kim Seonghun5ORCID,Kim Nam Hee6ORCID,Cho Eunae Sandra6ORCID,In Yook Jong6ORCID,Yoo Tae-Hyun5,Song Eunjoo7,Kim Pilhan278ORCID,Shin Eui-Cheol2ORCID,Chung Kyungsoo4ORCID,Choi Kyungsun3ORCID,Choi Chulhee123ORCID

Affiliation:

1. Department of Bio and Brain Engineering, KAIST, Daejeon 34141, Republic of Korea.

2. Graduate School of Medical Science and Engineering, KAIST, Daejeon 34141, Republic of Korea.

3. ILIAS Biologics Inc., Daejeon 34014, Republic of Korea.

4. Division of Pulmonology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.

5. Department of Internal Medicine, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.

6. Department of Oral Pathology, Oral Cancer Research Institute, Yonsei University College of Dentistry, Seoul 03722, Republic of Korea.

7. IVIM Technology, Daejeon 34051, Republic of Korea.

8. Graduate School of Nanoscience and Technology, KAIST, Daejeon 34141, Republic of Korea.

Abstract

Next generation exosome-based therapy can protect against systemic inflammation and sepsis-induced death.

Funder

National Research Foundation of Korea

Faculty research grant of Yonsei University College of Medicine

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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